Primary Cells and Laboratory Services that lead the way!

General List of Testing Methods and Biomarkers

All Products and Services are For Preclinical Research Purposes ONLY!

We can provide you with a ”Certificate of Analysis” for truly Normal Healthy Human Donor specimens.

We can detect the potential presence of diseases such as leukemias, breast, lung, colorectal, pancreatic, liver, prostate cancers, etc, in samples mistakenly ordered by researchers as Healthy Human Donor Samples but they may not actually be Healthy Human Donor Samples, just “Normal”!

AMONGST THE AVAILABLE TESTS:

Whole genome, exome, exome + mitochondrial sequencing, transcriptome profiling of mRNA, total RNA (mRNAs and non-coding RNA) or small RNAs (e.g., microRNA), 16s rRNA metagenomics analysis.

Diagnostic Tests and Biomarkers:

Flow cytometry

Leukemia/Lymphoma standard panel (27 biomarkers)

CD1, CD2, CD3, CD4, CD5, CD7, CD8, CD10, CD11c, CD13, CD14(Mo2), CD14(MY4), CD16, CD19, CD20, CD23, CD33, CD34, CD38, CD45, CD56, CD64, CD117, HLA-DR, Cytoplasmic kappa, Cytoplasmic lambda, Myeloperoxidase

Leukemia/Lymphoma extended panel (52 biomarkers)

CD1, CD2, CD3, CD4, CD5, CD7, CD8, CD10, CD11b, CD11c, CD13, CD14(Mo2), CD14(MY4), CD15, CD16, CD19, CD20, CD23, CD25, CD26, CD30, CD33, CD34, CD38, CD41b, CD45, CD56, CD57, CD64, CD71, CD103, CD117, CD123, CD138, CD200, CD235a, ZAP70,  FMC-7, HLA-DR, TCR alpha-beta, TCR gamma-delta, Cytoplasmic CD3, Surface kappa, surface lambda, Cytoplasmic kappa, Cytoplasmic lambda, Myeloperoxidase, HLA-DR, Glycophorin, TdT, bc-l2, CRLF-2

*Additional biomarkers and custom flow cytometry panels for each type of sample malignancy and for other types of cancers are available upon request.

Molecular analysis (ctNAs-NGS)

Any solid malignant neoplasm

Point Mutations (SNVs)(53 Genes)

AKT1,ALK,APC,AR,ARAF,ATM,BRCA1,BRCA2,CCND1,CDH1,CDK4,CDK6,CDK12,CDKN2A,CTNNB1,EGFR,ERBB2,ESR1,FGFR1,FGFR2,FGFR3,GATA3,GNA11,GNAQ,HRAS,IDH1,IDH2,KIT,KRAS,MAP2K1,MAP2K2,MET,MLH1,MTOR,MYCNF1,NFE2L2,NRAS,NTRK1,NTRK3,PDGFRA,PIK3CA,PTEN,RAF1,RET,RHEB,ROS1,SMAD4,SMO,STK11,TERT,TSC1,VHL

Deletion Variants (Indels)(30 Genes)

AKT1,ALK,APC,ATM,BRAF,BRCA1,BRCA2,CDH1,CDK12,CDKN2A,EGFR,ERBB2,ESR1,FGFR2,GATA3,HNF1A,HRAS,KIT,KRAS,MET,MLH1,NF1,PDGFRA,PIK3CA,PTEN,RET,ROS1,STK11,TSC1,VHL

Amplifications(18 Genes)

AR,BRAF,CCND1,CCND2,CCNE1,CDK4,CDK6,EGFR,ERBB2,FGFR1,FGFR2,KIT,KRAS,MET,MYC,PDGFRA,PIK3CA,RAF1

Fusions (13 Genes)

ALK,EGFR, FGFR1, FGFR2,FGFR3,NTRK1, NTRK2, NTRK3, RET,ROS1, BRAF, NRG1, RAF1

Lung, Breast, Hematological cancers

Genes (77)

ABA1, AKT1, ALK, APC, AR, ARAF, ATM, BRAF, BRCA1, BRCA2, CCND1, CCND2, CDH1, CDK6, CDKN2A, CREBBP, CTNNB1, EGFR, ERBB2, ERCC2, ESR1, EZH2, FBXW7, FGFR1, FGFR2, FGFR3, FLT3, GATA3, GNA11, GNAQ, GNAS, HNF1A, HRAS, IDH1, IDH2, JAK1, JAK2, JAK3, KEAP1, KIT, KRAS, MAP2K1, MAP2K2, MAPK1, MED12, MET, MLH1, MTOR, MYC, NF1, NFE2L2, NOTCH1, NRAS, NTRK1, NTRK3, PDGFRA, PIK3CA, PIK3R1, PPP2R1A, PTEN, PTPN11, RAF1, RB1, RET, RHEB, RHOA, RIT1, ROS1, SF3B1, SMAD4, SMO, SPOP, STK11, TERT, TP53, U2AF1, VHL

Fusion ctDNAs (10)

ALK, FGFR2, FGFR3, NTRK1/2/3, PD-L1, RET, ROS1, TMPRSS2

Fusion ctRNAs(36)

ALK, EGFR, AR, BRAF, CTNNB1-PLAG1, ERG, MYB-NFIB, NRG1, NTRK1/2/3, PAX3-FOXO1, PAX8-PPARG, FLI1, MET, ESR1, ETV1/4/5, FGFR1, FGFR2, FGFR3, AXL-MBIP, CLIP1-LTK, DNAJB1-PRKACA, RSPO2, RSPO3, SLC45A3, TFE3, THADA, TMPRSS, ERBB4, RES, RET, SSX1, SSX2

MSI (6)

BAT25, BAT26, NR21, NR24, NR27, MONO27

Breast, Endometrial and Ovarian cancers [Minimum standard panel (24 Genes)]

ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, EPCAM, FANCC, FANCM, MLH1, MSH2, MSH6, Mutyh, NF1, PALB2, PMS2, POLD1, PTEN, RAD51C, RAD51D, RECQL, STK11, TP53, CHEK2

Breast cancer extended panel (50 Genes)

AKT1,ALK,APC,AR,ARAF,BRAF,CCND1,CCND2,CCND3,CDK4,CDK6,CHEK2,CTNNB1,DDR2,EGFR,ERBB2,ERBB3,ESR1,FBXW7,FGFR1,FGFR2,FGFR3,FGFR4,FLT3,GNA11,GNAQ,GNAS,HRAS,IDH1,IDH2,KIT,KRAS,MAP2K1,MAP2K2,MET,MTOR,MYC,NRAS,NTRK1,NTRK3,PDGFRA,PIK3CA,PTEN,RAF1,RET,ROS1,SF3B1,SMAD4, SMO, TP53

Breast cancer fusion transcripts (12 transcripts)

ALK, BRAF, ERG, ETV1, FGFR1, FGFR2, FGFR3, MET, NTRK1, NTRK3, RET, ROS1

Lung cancer NSCLC (38 Genes)

ALK, BRAF, EGFR, ERBB2, RET, KRAS, MET, ROS1, STK11, NTRK1, AKT1, CCND1, CDKN2A, CTNNB1, ESR1, FGFR1, FGFR2, FGFR3, GATA3, GNA11, GNAQ, GNAS, HRAS, IDH1, IDH2, KIT, MAP2K1, MYC, NFE2L2, NRAS, NTRK1, NTRK3, PDGFRA, PIK3CA, PPP2R1A, PTEN, TP53, U2AF1

Colorectal cancer (43 Genes)

AKT1,APC,ARID1A,ATM,BAT25,BAT26,BAT34C4,BAT40,BRAF,CTNNB1,EGFR,ERBB2,FBXW7,GNAS,BAT26,KMT2C,KMT2D,KRAS,MET,MLH1,MLH3,MONO27,MSH2,MSH3,MSH6,MTHFR,MYC,NR21,NR22,NR24,MTHFR,NF1,NF2,NOTCH1,NPM1,NRAS,PIK3CA,PMS1,PMS2,POLE,PTEN,PVT1,RNF43,SMAD4,STK11,STK11,VEGFA,ZFHX3

 *Additional gene panels for other types of cancers are available upon request.